3DViewer can be used to visualize molecular dynamics (MD) simulation trajectory snapshots of the modelled SynGAP missense variants. The user can move between three 150 ns replica simulations (˅) and between five models (><), including the initial variant model and MD simulations snapshots for 0 ns, 50 ns, 100 ns and 150 ns.
The table section provides additional information for each variant, including a detailed description of the structural effects of the missense mutation, structural annotation, relevant MD simulation metrics (e.g., RMSD, B-factor) and data plots (e.g., Ramachandran, RMSD), and sequence- and physics-based predictions (e.g., SIFT, PolyPhen-2) and official ClinVar status. Currently, structural modelling is provided for SynGAP missense variants that have a template within the scope of SynGAP model (residues from 198 to 730).